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Ascendis Pharma A/S

ASNDHealthcareNASDAQ

Biotechnology

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Financials · Annual
Revenue
$720.1M
+98.0% YoY
Net Income
-$228.0M
+39.7% YoY
EBITDA
-$114.3M
+60.6% YoY
Free Cash Flow
$118.2M

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About Ascendis Pharma A/S

Ascendis Pharma A/S, operates as a biopharmaceutical company that focuses on developing TransCon-based therapies for unmet medical needs in Europe, the United States, and internationally. Valued at $13.52B, ASND is a large-cap name in its sector. The company offers SKYTROFA for treating pediatric patients with growth hormone deficiency; and YORVIPATH, a once-daily subcutaneous injection for the treatment of adults with chronic hypoparathyroidism.

Key stats
Market Cap$13.52B
P/E (TTM)24.81
Fwd P/E19.92
EPS$8.82
52W Change+25.5%
ROE332.6%
Analysis

Ascendis Pharma A/S carries $896.7M in total debt against $572.8M in cash reserves — debt is roughly 1.6x the cash position. Managing this leverage effectively will be important for long-term financial stability. Free cash flow comes in at $118.2M, providing flexibility for reinvestment, buybacks, or dividends. Consistent free cash flow generation is often considered a sign of operational health. ROE of 332.6% points to exceptionally high capital efficiency, indicating how much profit the company produces per dollar of shareholder equity. Revenue has grown from $51.2M (2022) to $720.1M (2025), reflecting a 1307% increase over the period.

Investors considering Ascendis Pharma A/S should weigh the typical risks associated with ASND's sector, size, and financial profile against their own risk tolerance and investment objectives. These risk factors are not exhaustive — macroeconomic shifts, regulatory changes, and competitive dynamics can all influence Ascendis Pharma A/S's trajectory.

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