Castle Biosciences, Inc.
CSTLHealthcareNASDAQDiagnostics & Research
Scan Results
Daily timeframeCastle Biosciences, Inc., a molecular diagnostics company, provides test solutions for the diagnosis and treatment of dermatologic cancers, Barrett's esophagus (BE), atopic dermatitis (AD), and uveal. Valued at $644.8M, CSTL is a small-cap name in its sector. The company offers DecisionDx-Melanoma, a risk stratification gene expression profile (GEP) test that predicts the likelihood of a positive sentinel lymph node and the risk of metastasis for patients with invasive cutaneous melanoma; TissueCypher, a risk stratification spatialomics test to predict future development of high-grade dysplasia and/or esophageal cancer in patients with non-dysplastic, indefinite dysplasia, and low-grade dysplasia BE; AdvanceAD-Tx, a non-invasive GEP test which is designed to guide systemic treatment selection for patients aged 12 years and older with moderateto-severe AD; DecisionDx-SCC, a GEP test for cutaneous squamous cell carcinoma; and MyPath Melanoma, a diagnostic GEP test for use in patients with difficult-to-diagnose melanocytic lesions.
Market Cap
$644.8M
Beta
1.11
P/E (TTM)
—
P/E (Fwd)
-23.59
EPS (TTM)
$-0.42
EPS (Fwd)
$-0.90
ROE
-2.9%
ROA
-4.0%
Cash
$261.7M
Total Debt
$36.7M
Free CF
$12.9M
52W Change
33.3%
Annual Financials
Cash vs Debt
Castle Biosciences, Inc. holds $261.7M in cash against $36.7M in total debt, giving it a net cash position. This means the company could theoretically pay off all its debt and still have cash remaining. Annual free cash flow of $12.9M supports ongoing capital allocation decisions and provides a cushion against unexpected expenses or downturns. ROE of -2.9% points to negative capital efficiency, indicating how much profit the company produces per dollar of shareholder equity. Revenue has grown from $137.0M (2022) to $344.2M (2025), reflecting a 151% increase over the period.
The strong cash position relative to debt provides a financial cushion that reduces balance sheet risk. These risk factors are not exhaustive — macroeconomic shifts, regulatory changes, and competitive dynamics can all influence Castle Biosciences, Inc.'s trajectory.