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Castle Biosciences, Inc.

CSTLHealthcareNASDAQ

Diagnostics & Research

PriceMA150MA200
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Indicator snapshot
MA150-31.10%
$30.86

Price below medium-term moving average.

MA200-25.96%
$28.72

Below long-term trend line.

RSI-14neutral
48.3

Balanced. Not overbought, not oversold.

MACDpositive
+0.2307

Histogram positive — upward momentum.

Financials · Annual
Revenue
$344.2M
+3.7% YoY
Net Income
-$24.2M
-232.4% YoY
EBITDA
$11.3M
-70.3% YoY
Free Cash Flow
$12.9M

Scan Results

Daily timeframe
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About Castle Biosciences, Inc.

Castle Biosciences, Inc., a molecular diagnostics company, provides test solutions for the diagnosis and treatment of dermatologic cancers, Barrett's esophagus (BE), atopic dermatitis (AD), and uveal. Valued at $644.8M, CSTL is a small-cap name in its sector. The company offers DecisionDx-Melanoma, a risk stratification gene expression profile (GEP) test that predicts the likelihood of a positive sentinel lymph node and the risk of metastasis for patients with invasive cutaneous melanoma; TissueCypher, a risk stratification spatialomics test to predict future development of high-grade dysplasia and/or esophageal cancer in patients with non-dysplastic, indefinite dysplasia, and low-grade dysplasia BE; AdvanceAD-Tx, a non-invasive GEP test which is designed to guide systemic treatment selection for patients aged 12 years and older with moderateto-severe AD; DecisionDx-SCC, a GEP test for cutaneous squamous cell carcinoma; and MyPath Melanoma, a diagnostic GEP test for use in patients with difficult-to-diagnose melanocytic lesions.

Key stats
Market Cap$644.8M
Fwd P/E-23.59
EPS$-0.42
Beta1.11
52W Change+33.3%
ROE-2.9%
Analysis

Castle Biosciences, Inc. holds $261.7M in cash against $36.7M in total debt, giving it a net cash position. This means the company could theoretically pay off all its debt and still have cash remaining. Annual free cash flow of $12.9M supports ongoing capital allocation decisions and provides a cushion against unexpected expenses or downturns. ROE of -2.9% points to negative capital efficiency, indicating how much profit the company produces per dollar of shareholder equity. Revenue has grown from $137.0M (2022) to $344.2M (2025), reflecting a 151% increase over the period.

The strong cash position relative to debt provides a financial cushion that reduces balance sheet risk. These risk factors are not exhaustive — macroeconomic shifts, regulatory changes, and competitive dynamics can all influence Castle Biosciences, Inc.'s trajectory.

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