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Ultragenyx Pharmaceutical Inc.

RAREHealthcareNASDAQ

Biotechnology

PriceMA150MA200
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Indicator snapshot
MA150-11.92%
$26.56

Price below medium-term moving average.

MA200-14.92%
$27.49

Below long-term trend line.

RSI-14neutral
43.8

Balanced. Not overbought, not oversold.

MACDnegative
-0.3541

Histogram negative — downward momentum.

Financials · Annual
Revenue
$673.0M
+20.2% YoY
Net Income
-$575.0M
-1.1% YoY
EBITDA
-$474.0M
-1.3% YoY
Free Cash Flow
-$219.1M

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About Ultragenyx Pharmaceutical Inc.

Ultragenyx Pharmaceutical Inc., a biopharmaceutical company, focuses on the identification, acquisition, development, and commercialization of novel products for the treatment of rare and ultra-rare. With a market capitalization of $2.30B, it sits in mid-cap territory. Its biologic products include Crysvita (burosumab), an antibody targeting fibroblast growth factor 23 for the treatment of X-linked hypophosphatemia, as well as tumor-induced osteomalacia; Mepsevii, an enzyme replacement therapy for the treatment of children and adults with Mucopolysaccharidosis VII; Dojolvi for the treatment of long-chain fatty acid oxidation disorders; and Evkeeza (evinacumab) for the treatment of homozygous familial hypercholesterolemia.

Key stats
Market Cap$2.30B
Fwd P/E24.23
EPS$-6.16
Beta0.39
52W Change-33.2%
Analysis

On the balance sheet, RARE has $413.0M in cash with $1.20B in obligations. The ability to service this debt comfortably depends on continued operational cash generation. The company is burning cash, with free cash flow at -$219.1M. This typically occurs when a company is investing aggressively in growth, but sustained cash burn can strain the balance sheet. Revenue has grown from $363.3M (2022) to $673.0M (2025), reflecting a 85% increase over the period.

With a beta below 0.7, Ultragenyx Pharmaceutical Inc. typically sees smaller price swings than the overall market, offering a degree of stability during turbulent periods. The company is burning cash at the operating level, which is not unusual for growth-phase companies but adds risk if it persists. It is important to consider these factors alongside broader market conditions and individual financial goals when reviewing RARE.

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